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Hamster Hepatic Amyloid A (AA) Protein is Derived from a Novel Member of the SAA Gene Family
Author(s) -
NIEWOLD TH. A.,
MURPHY C.,
GRUYS E.
Publication year - 1994
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1994.tb03364.x
Subject(s) - hamster , gene , amyloid (mycology) , family member , serum amyloid a , genetics , biology , microbiology and biotechnology , medicine , pathology , family medicine , inflammation
The nearly complete amino acid sequence of casein‐induced hepatic hamster AA is described. Hamster AA appeared to be C‐terminally ragged as found in other species. Furthermore, the N‐terminus was (partially) truncated. Hamster hepatic AA sequence showed high homology with, but was not identical to hamster SAA‐isotype sequences deduced earlier from mRNA in hepatic and extra‐hepatic tisstie. Therefore, hamster hepatic AA is derived from a novel member of the SAA gene family. However, the origin of hepatic AA‐amyloid remains unclear.