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Population Dynamics of CD4 + T Cells Lacking Thy‐1 in Murine Retrovirus‐Induced Immunodeficiency Syndrome (MAIDS)
Author(s) -
MOUTSCHEN M. P.,
COLOMBI S.,
DEPREZ M.,
WIJK F.,
HOTERMANS C.,
MARTIN M.T.,
GREIMERS R.,
BONIVER J.
Publication year - 1994
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1994.tb03363.x
Subject(s) - retrovirus , virology , immunodeficiency , dynamics (music) , population , biology , medicine , immunology , virus , physics , environmental health , immune system , acoustics
Increased numbers of CD4 + Thy‐1 cells have been described in the spleen (SP) of mice with retrovirusinduced immunodeliciency (MAIDS). Since this phenotypic abnormality might have considerable functional importance, the expansion of the CD4 + Thy‐1 subset in MAIDS was characterized further. CD4 + Thy‐1 − and Thy‐1 + T‐cell is from infected mice expressed similar densities of CD3 and TCR γ/β. In contrast, the Thy‐I − subset was uniformly CD44 hi , even early in the disease when part of Thy‐I + cells were still CD44 10 . The emergence of CD4 + Thy‐1 − cells occurred first in SP and lymph nodes and was observed later in thymus. The important fraction ofCD4 + cells lacking Thy‐1 normally present in Peyer's patches was only weakly modified. Despite the major expansion of the CD4 + Thy‐1 − phenotype. the proliferating fraction was not higher in this subset than in CD4 + Thy‐1 + cells from infeeted miee. Persistence after hydroxyurea administration was identical in both subsets, indicating similar mean cell lifespans. Taken together, these results show that the major expansion of CD4 + Thy‐I − T‐cells in MAIDS is not ascribable solely to increased proliferation within this subset. Phenotypic analysis suggests that CD4 + Thy‐I − cells result from the differentiation of Thy‐I + cells induced by activation signals related to retroviral infection.