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Functional and Biochemical Properties of a Mouse Placental Immunoregulatory Factor
Author(s) -
BOBÉ P.,
BLEUX C.,
KANELLOPOULOSLANGEVIN C.
Publication year - 1994
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1994.tb03355.x
Subject(s) - immune system , in vivo , placenta , concanavalin a , pronase , immunology , antigen , biology , fetus , endocrinology , in vitro , pregnancy , trypsin , biochemistry , genetics , enzyme , microbiology and biotechnology
The authors have a long standing interest in immune regulations which control the absence of rejection of a semi‐allogeneic fetus by the mother. A previous work described a soluble 40 kDa factor extracted from mouse placenta and capable of inhibiting secondary immune responses in vivo. The present paper reports the following on its mode of action in vivo : (1) it is active even in a fully allogeneic host; (2) it can be administered i. v. or i. p. along with antigen; and (3) the injections of factor and antigen must not be more than 2 days apart for maximum efficacy. Moreover, the results of the study described here indicate also that this factor is a concanavalin A‐binding giycoprotein, sensitive to heat and pronase, and different from interleukin 10 (IL‐10). Thus, this placental factor appears to be different from previously described immune regulators such as IL‐10 and could contribute significantly to immune regulations at the level of the placenta.