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Bacterial Lysates and Ribosomes as Inducers of Specific Immune Responses: a Comparative Study
Author(s) -
BéNé M. C,
KAHL L.,
PERRUCHET A. M.,
HERMES H.,
MOSGES M.,
NORMIER G.,
BINZ H.,
FAURE G. C.
Publication year - 1993
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1993.tb02594.x
Subject(s) - haemophilus influenzae , tonsil , streptococcus pneumoniae , microbiology and biotechnology , immune system , antibody , streptococcus pyogenes , klebsiella pneumoniae , lysis , biology , ribosome , streptococcus , immunology , bacteria , chemistry , escherichia coli , antibiotics , biochemistry , rna , genetics , gene , staphylococcus aureus
A bacterial lysate (OM‐85 BV), a preparation of purified bacterial ribosomes (D53) and a placebo were tested for ability to induce the local appearance of specific antibody‐containing cells. The three compounds were given orally to 90 children who required tonsillectomy. Surgery was carried out after 1 month of therapy. Frozen‐cut sections of each tonsil were tested in indirect immunofluorescence. Cells containing antibodies directed to Streptococcus pneumoniae. Streptococcus pyogenes. Haemophilus influence or Klebsiella pneumoniae were enumerated. Lowest values were noted in the placebo group. Slightly higher numbers were observed after treatment with OM‐85 BV, but significant increases were noted only for the elevated numbers of specific antibody‐containing cells observed after D53 therapy. Bacterial ribosomal preparations thus contribute efficient induction of specific local immune responses in man.