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Preferential Vδ1 Expression among TcR γ/δ ‐Bearing T Cells in Human Oral Epithelium
Author(s) -
PEPIN L. F.,
ROGER T.,
MORISSET J.,
SEMAN M.
Publication year - 1993
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1993.tb02556.x
Subject(s) - delta , cd8 , t cell receptor , oral mucosa , microbiology and biotechnology , epithelium , biology , connective tissue , cd3 , pathology , population , t lymphocyte , t cell , immunology , chemistry , antigen , medicine , anatomy , immune system , environmental health , engineering , aerospace engineering
The oral cavity is a septic area colonized by various bacterial species, and the oral mucosa is frequently submitted to microtraumas. Several mechanisms are implicated in the defence of the oral tissue, but little is known concerning the eventual presence and role of γ/δ T cells at this site. Samples of healthy keratinized oral mucosa were examined with immunochemica! techniques using anti‐CD3, CD4, CD8, CD22, TcRδ1, Vδl and Vδ2 monoclonal antibodies. Whatever the site examined. γ/δ T cells represent at most 2% of the T‐cell population, a value similar to that found in other tissues. In the connective tissue, under the basement membrane, Vδ2 + γ/δ T cells are predominant whereas the epithelium mostly contains Vδ + γ/δ T cells. The significance of this preferential Vδ1 intraepithelial presence is discussed.