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Immunobiological Studies on Experimental Visceral Leishmaniasis. III. Cytokine‐Mediated Regulation of Parasite Replication
Author(s) -
SAHA B.,
BASAK S. K.,
ROY S.
Publication year - 1993
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1993.tb01751.x
Subject(s) - parasite hosting , biology , visceral leishmaniasis , leishmania donovani , immunology , cytokine , replication (statistics) , leishmania , disease , interleukin 4 , leishmaniasis , virology , medicine , pathology , world wide web , computer science
The role of T‐cell‐derived cytokines in the regulation of Leishmania donovani replication was studied in a murine model. It was observed that in H‐2 d mice at the early and later stages of the disease IFN‐γ‐secreting T cells predominate, whereas in between the above stages IL‐4–secreting T cells predominate. Possibly, IL‐4 abrogates the protective ability of IFN‐γ and thereby exponential parasite growth is ensured at the active stage of the disease. By contrast, H‐2 b mice were possibly incapable of inducing IL‐4‐secreting T cells and therefore parasite replication remains under control at any point post infection.