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Staphylococcal Enterotoxin B Promotes Deletion and Functional Inactivation of CD4Vβ8‐Positive Cells in the Absence of CD8 T Cells
Author(s) -
WILLIAMS O.,
GONZALO J. A.,
MARTÍNEZA C.
Publication year - 1993
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1993.tb01722.x
Subject(s) - enterotoxin , cd8 , cytotoxic t cell , biology , t cell , interleukin 21 , effector , microbiology and biotechnology , in vivo , immunology , chemistry , immune system , in vitro , gene , escherichia coli , genetics
The staphylococcal enterotoxins stimulate discrete subsets of T cells depending on their expression of particular V genes. Among these, staphylococcal enterotoxin B (SEB) vigorously stimulates Vβ8 + cells. This stimulation results in proliferation of both CD4 + Vβ8 + and CDS + T cells and eventually to anergy and clonal deletion in the former subset. We have examined the possible role of CD8 + T cells in the response of CD4 + cells to SEB, by in vivo CD8 + T‐cell‐depletion. We found no qualitative difference in the responses of untreated and CD8 + T‐cell depleted mice to SEB; however, a small quantitative difference in deletion was observed. Thus it appears that on the whole the response of CD4 + Vβ8 + T cells to SEB is independent of CD8 + T‐cell effector function, although the latter may play a partial role.