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T‐Cell Responsiveness to LCMV Segregates as a Single Locus in Crosses between BALB/cA and C.B‐17 Mice. Evidence for Regulation by a Gene Outside the Igh Region
Author(s) -
CHRISTENSEN J. P.,
MARKER O.,
THOMSEN A. R.
Publication year - 1993
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1993.tb01717.x
Subject(s) - lymphocytic choriomeningitis , biology , congenic , locus (genetics) , virus , gene , immune system , virology , balb/c , t cell , antibody , b cell , genetics , immunology , microbiology and biotechnology , cd8
The course of systemic infection with lymphocytic choriomeningitis virus (LCMV) was studied in BALB/ cA and C.B‐17 mouse strains differing in the immunoglobulin heavy chain region (Igh). Susceptibility to intracerebral infection and the ability to clear the virus differed significantly between these presumably congenic strains, suggesting that a gene in the Igh region might influence the course of this infection. A difference in virus spread prior to appearance of the immune response could not explain the observed differences. On the other hand, the differences in course of infection correlated with a difference in virus‐specific T‐cell responsiveness measured in terms of virus‐specific cytotoxicity in vitro and delayed‐lype hypersensitivity in vivo . Analysis of F 1 , BC 1 and F2 progeny showed that differential T‐cell responsiveness was influenced hy a single gene or gene complex; however, no linkage was found between this locus and the Igh‐C region. Taken together, these results indicate that an additional, and previously unknown, genetic difference exists between these two mouse strains, and that the involved locus carries a gene which significantly affects T‐cell responsiveness to LCMV.