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Antibody Response to Pneumococcal Polysaccharide Vaccine in Young, Adult and Old Mice
Author(s) -
AABERGE I. S.,
NORTH R. J.,
GROENG E.C.,
LØVIK M.
Publication year - 1993
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1993.tb01689.x
Subject(s) - immunization , antibody , immune system , serotype , antigen , immunology , pneumococcal polysaccharide vaccine , antibody response , streptococcus pneumoniae , pneumococcal vaccine , pneumococcal infections , biology , medicine , virology , microbiology and biotechnology , pneumococcal disease , antibiotics
The anti‐pneumococcal antibody response was studied in young (5‐week‐old) and adult (10‐week‐old) BALB/c and CBA/J mice and in adult (9–10‐week‐old) and old (12‐, 18‐ and 24‐month‐old) AB6F 1 and B6D2F 1 mice after s.c. immunization with a 23‐valent pneumococcal polysaccharide vaccine. Both young and adult mice showed a significant IgM antibody response to the vaccine 6 days after immunization with 111 /ig antigen. There were significant immune responses to serotypes 1, 2, 4 and 7F in contrast to small responses to serotypes 14, 19F and 23F after immunization with the vaccine. One month after immunization, there were only marginal differences in IgM anti‐pneumococcal antibody levels to the vaccine (anti‐PPS) between immunized and unimmunized BALB/c mice, whereas in CBA/J mice the anti‐PPS remained higher in immunized than in unimmunized mice. Immunization of old mice induced a significant IgM antibody response 6 days after immunization, but the anti‐PPS thereafter decreased rapidly towards preimmunization values in AB6F 1 mice. A significant IgG anti‐PPS was not detected in any of the mice studied. The IgA anti‐PPS tended to vary over time with no consistent pattern. It is important to carefully consider age and strain of the mice used when studying the immune response to pneumococcal polysaccharide antigens.