Premium
IFN‐γ is directly Cytostatic to the Extracellular Form (Promastigote) of Leishmania donovani
Author(s) -
BHATTACHARYA S.,
MANNA P. P,
BANDYOPADHYAY S.
Publication year - 1993
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1993.tb01683.x
Subject(s) - leishmania donovani , in vitro , biology , cytotoxicity , cytotoxic t cell , microbiology and biotechnology , lysis , leishmania , chemistry , leishmaniasis , immunology , biochemistry , visceral leishmaniasis , parasite hosting , world wide web , computer science
We investigated the effect of various human cytokines on the in vitro growth of Leishmania donovani (L. donovani ) promastigotes. rhIFN‐α, rhIFN‐β, rhIL‐1, rhIL‐2, rhIL‐3, rhIL‐4, rhIL‐6 and rhM‐CSF had no effect. By contrast. rhIFN‐γ was directly growth inhibitory to L. donovani promastigotes in a dose‐dependent manner. Anti‐IFN‐γ antibody, but neither anti‐IFN‐α nor an ti‐IFN‐β antibody, abolished this promastigote growth Inhibitory effect of rhIFN‐γ. L. donovani promastigotes were not lysed by rhIFN‐γ as determined by 51 Cr‐release assay. These data indicate that rhIFN‐γ is cytostatic. not cytotoxic, to L. donovani promastigotes.