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Cell‐Mediated Immune Responses in Renal Transplant Recipients treated with Cyclosporin and Prednisolone with or without Azathioprine
Author(s) -
WRAMNER L.,
MJÖRNSTEDT L.,
RYDBERG L.,
OLAUSSON M.
Publication year - 1993
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1993.tb01679.x
Subject(s) - azathioprine , prednisolone , medicine , kidney transplantation , transplantation , lymphocyte , immune system , immunology , gastroenterology , kidney , disease
The cell‐mediated immune response was studied, using mixed lymphocyte reactivity (MLR) and cell‐mediated lympholysis (CML) tests, in patients with well‐functioning kidney grafts from living donors at 6 and 12 months and at 2–5 years after transplantation. The patients were allocated to treatment with cyclosporin A (CyA) and prednisolone (group A) or with CyA, prednisolone and azathioprine (group B). The MLR towards a third party were in the range of that of untreated controls while the anti‐donor activities were reduced after 6 months in both groups. The CML activities in group A towards a third party were in the range of that of untreated controls at all times, while the anti‐donor activities were decreased. By contrast, the CML activities in group B towards a third party were decreased during the first year and were in the range of that of normal controls at 2–5 years. The anti‐donor CML activities were low at all times in group B. In summary, the two CyA protocols allowed the induction of donor‐specific unresponsiveness within the first post‐transplant year. The anti‐third party activities were low during the first post‐transplant year in recipients with triple therapy but not in those without azathioprine.