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Tumour‐Like Localized Amyloid of the Brain is derived from Immunoglobulin Light Chain
Author(s) -
ERIKSSON L.,
SLETTEN K.,
BENSON L.,
WESTERMARK P.
Publication year - 1993
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1993.tb01673.x
Subject(s) - choroid plexus , immunoglobulin light chain , pathology , amyloidosis , autopsy , antibody , amyloid (mycology) , peptide sequence , chemistry , ventricle , homology (biology) , biology , microbiology and biotechnology , amino acid , medicine , biochemistry , central nervous system , immunology , endocrinology , gene
A patient is presented in whom the amyloid component of an intracerebral‘amyloidoma’has been purified and characterized by amino acid sequence analysis. The material originated from an autopsy of a 76‐year‐old man who 15 years earlier had been operated for an intracerebral‘amyloid tumour'. The tumour had recurred and grown to an almost walnut‐sized mass in the right cerebral hemisphere. It was located in the parietal lobe close to the lateral ventricle and had a close connection to the choroid plexus. Histological examination showed large masses of amyloid surrounded by some plasma cells and a few macrophages of the foreign body type, Amino acid sequence analysis of a major fibril subunit protein showed homology with the variable region of a monoclonal lambda immunoglobulin light chain, subgroup III or IV. This shows that the amyloid in the ‘tumour’ was of AL type and presumably derived from local synthesis by plasma cells.