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Coding Region Polymorphisms of Human T‐Cell Receptor Vβ6.9 and Vβ21.4
Author(s) -
HANSEN T.,
RØNNINGEN K. S.,
PLOSKI R.,
KIMURA A.,
THORSBY E.
Publication year - 1992
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1992.tb03101.x
Subject(s) - rheumatoid arthritis , single nucleotide polymorphism , myasthenia gravis , coeliac disease , allele , autoimmune disease , coding region , genetics , t cell receptor , genotype , biology , immunology , medicine , microbiology and biotechnology , t cell , gene , disease , antibody , immune system
Two new TCR V β coding region polymorphisms were identified: V β6.9a/b and V β21.4a/b. In both cases, a single nucleotide difference gives rise to an amino acid exchange. Genomic typing by the PCR/sequence‐specific oligonucleotide probing technique was performed to study a possible contribution of these two new polymorphisms in susceptibility to autoimmune diseases. However, there was no association with insulin‐dependent diabetes mellitus, rheumatoid arthritis, juvenile rheumatoid arthritis, multiple sclerosis, myasthenia gravis or coeliac disease. On the other hand, significant differences were found between Caucasoid and Oriental populations in frequencies of the V β6.9 and V β21.4 alleles.