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Common Variable Immunodeficiency with Increased Surface igM‐Positive Double‐Bearing B Cells
Author(s) -
MOTOYOSHI F.,
MORI S.,
KONDO N.,
KANRKO H.,
OZAWA T.,
KUWABARA N.,
KATO Y.,
TAKEMURA M.,
NOMA A.,
ORII T.
Publication year - 1992
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1992.tb02936.x
Subject(s) - common variable immunodeficiency , pokeweed mitogen , messenger rna , stimulation , immunology , biology , immunodeficiency , microbiology and biotechnology , immune system , antibody , in vitro , endocrinology , gene , genetics , peripheral blood mononuclear cell
We report a case of common variable immunodeficiency (CVI) that shows low levels of IgG and IgA, but a normal quantitative or qualitalive level of IgM. T‐cell functions were not disturbed. Increased numbers of surface IgM (sIgM) and sIgD, sIgM and sIgA, sIgM and sIgA double bearing B cells were observed as compared with a control. No IgG and IgA induction upon stimulation with Staphylococcus aureus Cowan I (SAC)and recombinant interleukin‐2(rIL‐2), or pokeweed mitogen (PWM) and rIL‐4 or rIL‐6 was observed, although there was proliferation. Although; μ mRNA was expressed as much as in a healthy control, transcription of γ mRNA and α mRNA was very low. Furthermore, no enhanced effects of γ mRNA and α mRNA were recognized upon stimulation with rIL‐4 and rIL‐6. These results suggest that the patient's B cells might be detective at the switching process from μ, μ and δ, μ and γ to γ or μ and α to α.