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The Effects of Interleukins 4 and 5 on the Differentiation of B Cells from (NZB × NZW)F1 Mice
Author(s) -
ALARCÓNRIQUELME M. E.,
MÖLLER G.,
FERNÁNDEZ C.
Publication year - 1991
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1991.tb03742.x
Subject(s) - polyclonal antibodies , antibody , biology , immunology , ratón , microbiology and biotechnology , interleukin , dna synthesis , endocrinology , dna , chemistry , cytokine , biochemistry
We describe here that IL‐4and IL‐5 together can induce the production of high amounts of IgG1 polyclonal antibodies by B cells from old (NZB × NZW)F1 mice even in the absence of LPS. The effect was less marked in young mice from the same strain or in normal Balb/c mice. The cells sensitive to the treatment with the interleukins were the large B cells. Old mice had higher proportions of such cells than young mice or normal Balb/c mice. Synthesis of anti‐DNA antibodies of the IgM class was induced. Although IL‐4 plus IL‐5 induced a strong polyclonal IgG1 production, there were no IgG1 anti‐DNA antibodies.