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Mechanisms of Generation of Antibody Diversity as a Cause for Natural Selection of Homoiothermal Animals in the Process of Evolution
Author(s) -
ZAV'YALOV V. P.,
TISHCHENKO V. M.
Publication year - 1991
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1991.tb02550.x
Subject(s) - natural selection , selection (genetic algorithm) , diversity (politics) , evolutionary biology , process (computing) , natural (archaeology) , biology , antibody , computational biology , genetics , computer science , artificial intelligence , paleontology , law , political science , operating system
The temperature‐dependence of domain interactions in the Fab, Fc. Fb and Fv fragments from humar myeloma immunoglobulins (IgG) samples was investigated by scanning microcalorimetry, NMR and difference spectroscopy. The fragments were found lo be very sensitive to temperature changes. Lowering the temperature below the physiological value 37°C) considerably decreases the energy of interaction of the variable V H and V L domains, resulting at limes in their dissociation. Since the association energies of V H and V L pairs can be affected by the result of somatic recombination and mutation events affecting antibody genes, immunoglobulins can fortuitously acquire The properties of cryoglobulins or cold autoantibodies and induce severe pathological states. It is postulated that this property of immunoglobulins, and by extension, of T‐cell antigen receptors might have been one of the causes for the possible natural selection of homoiothermal animals. In these, the high conformational sensitivity of immunoglobulins to temperature change may be important in the mechanisms of induction of secondary functions In immune responses.