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Interferon‐Gamma Enhances PAF‐Acether Production by Stimulated Human Polymorphonuclear Leucocytes
Author(s) -
GEFFNER J. R.,
SCHATTNER M. A.,
LAZZARI M. A.,
ISTURIZ M. A.
Publication year - 1991
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1991.tb02528.x
Subject(s) - platelet activating factor , recombinant dna , immune system , interferon γ , chemistry , interferon gamma , neutrophile , platelet , immunology , interferon , granulocyte , microbiology and biotechnology , in vitro , biology , biochemistry , gene
Human polymorphonuclear leucocytes (PMN) stimulated with either immune complexes (IC), phorbol myristate acetate (PMA) or N‐formyl‐methionyl‐leucyl‐phenylalanine (FMLP) generate platelet‐activating factor (PAF‐acether), The present study demonstrates that treatment of PMN with recombinant human interferon‐gamma (IFN‐y) significantly enhanced the production of PAF‐acether by stimulated cells, in a concentration‐dependent mode. On the contrary, α and β IFN were completely unable to increase PAF‐acether synthesis by stimulated PMN. The significance of these results is discussed.