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Highly Polymorphic Domains of the Human Serum Amyloid A (SAA) Gene GSAA1
Author(s) -
SACK G.H.,
TALBOT C.C.
Publication year - 1991
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1991.tb01797.x
Subject(s) - intron , polymerase chain reaction , genetics , biology , gene , mendelian inheritance , oligonucleotide , microbiology and biotechnology , dna
The DNA of the human serum amyloid A (SAA) gene GSAA1 contains several repetitive regions within its introns. We have studied length variations al one such region in the 2nd intron by selective amplification using the polymerase chain reaction (PCR) and defined oligonucleotide primers. The lengths of the repetitive regions frequently differ between individual chromosomes and can be transmitted as Mendelian markers, making them useful for genetic linkage analysis.