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T‐Cell Regulation of CD5 + B‐Cell Activity in Normal Mice
Author(s) -
HUCHET R.,
GRANDJON D.,
HALLEPANNENKO O.
Publication year - 1991
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1991.tb01549.x
Subject(s) - microbiology and biotechnology , in vitro , cycloheximide , cell , chemistry , t cell , radioresistance , interleukin 21 , biology , cell culture , immunology , cytotoxic t cell , biochemistry , immune system , protein biosynthesis , genetics
The differentiation of plaque‐forming cell (PFC) precursors against bromelain‐treated syngeneic erythrocytes (Br MRBC) into PFC induced in vitro by LPS is down‐regulated by nylon non‐adherent (nylon‐passed–NP) T cells and by nylon adherent (NA) T cells, NA T cells are more potent inhibitors than NP T cells. This regulatory activity of NA and NP T cells results from an interaction between CD4 + radioresistant and CD4 + radiosensitive T cells. Furthermore CD4 + T cells from the NA fraction but not from the NP fraction are activated cells: their inhibitory activity is abrogated after preincubation with cycloheximide. These results are discussed within the overall framework of T‐cell regulation of autoimmune anti‐Br MRBC B‐cell subsets.