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The Human in Vitro Anti‐type 4 Pneumococcal Polysaccharide Antibody Response is Regulated by Suppressor T Cells
Author(s) -
GRIFFIOEN A. W.,
RIJKERS G. T.,
TOEBES E. A. H.,
ZEGERS B. J. M.
Publication year - 1991
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1991.tb01541.x
Subject(s) - antigen , in vitro , antibody , biology , cytotoxic t cell , t cell , immune system , immunology , microbiology and biotechnology , biochemistry
In order to study the regulation of the human B‐cell response to T‐cells independent type 2 (TI‐2) antigens, we analysed the role or T‐cells in the in vitro antibody response to type 4 pneumococcal polysaccharide (PS4). We found that T cells can positively regulate the in vitro antibody response to PS4 when they arc added into an in vitro B‐ceil culture system. In addition we demonstrated that T cells exert a negatively regulating activity. We found that T cells, when cultured for 24 h in the presence of high concentrations of PS4, can suppress the anti‐PS4 antibody response. This down‐regulation of the anti‐PS4 B‐cell response is shown to be antigen specific and MHC‐restricted. Furthermore, PS4‐specific T‐cell mediated suppression appears lo be radioresistant and confined to the T‐ceil preparations enriched for CD8 + cells. The results show that analogous to results obtained in mice, human T cells are able to exert a regulatory control of the antibody response to Ti‐2 antigens.