Premium
Loss of HLA Heavy Chain and β2‐Microglobulin in HLA Negative Tumours
Author(s) -
CABRERA T.,
CONCHA A.,
RUIZCABELLO F.,
GARRIDO F.
Publication year - 1991
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1991.tb01531.x
Subject(s) - beta 2 microglobulin , human leukocyte antigen , heavy chain , cytoplasm , biology , cancer research , antigen , hla a , microbiology and biotechnology , immunology , antibody
Expression of HLA class I antigens on the cell surface requires the association of heavy chain. endogenous peptide and β 2 ‐microglobulin (β 2 m). We have studied the expression of free class I heavy chain and β 2 m in cryostatic sections of 51 HLA class I negative human tumours of different origin. Selective low expression of β 2 m was observed only on the 9 colorectal adenocarcinomas. In contrast, simultaneous under‐expression of heavy chain and β 2 m was detected in the rest of the tumours studied. Our results suggest that the accumulation in the cytoplasm of HLA heavy chain in HLA negative colorectal carcinomas is a particular mechanism that cannot be applied lo all HLA negative tumours.