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Transmembrane Signalling via HLA‐DR Molecules on T Cells from a Sezary T‐Cell Leukaemia Line
Author(s) -
GEISLER C.,
KUHLMANN J.,
MØLLER T.,
PLESNER T.,
RUBIN B.
Publication year - 1990
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1990.tb03217.x
Subject(s) - clone (java method) , transmembrane protein , monoclonal antibody , hla dr , t cell , cell culture , microbiology and biotechnology , population , human leukocyte antigen , biology , antibody , chemistry , immunology , antigen , receptor , immune system , genetics , medicine , gene , environmental health
The human Sezary T‐cell leukaemia line. HUT.78, represents a population of activated T cells, i.e. they are HLA‐DR + and IL‐2R + . We have analysed the capacity of HUT.78cells (1) to stimulate HLA‐DR‐specific T‐cell lines or clones and (2) to be induced to synthesize IL‐2 by anti‐HLA‐DR monoclonal antibodies. The results of our experiments show that HLA‐DR molecules on HUT.78 cells can stimulate at least one HLA‐DR‐specific T‐cell clone and can act as transmembrane signal transmitters.