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Immunological Tolerance to Many Self Epitopes may be Unnecessary
Author(s) -
PREHN R. T.
Publication year - 1990
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1990.tb02923.x
Subject(s) - self tolerance , epitope , immunology , biology , antigen , antibody , autoimmunity
The demonstration of the existence of antigenic mimicry suggests that immunological tolerance to self antigens may be an insufficient basis for distinguishing self from non‐self. However, some data suggest that even in the absence of tolerance most self epitopes would not immunize the host and that tolerance to all self epitopes may, therefore, not be necessary for the prevention of autoimmune disease.