Premium
Antigen‐Presenting Activity of Non‐Langerhans Epidermal Cells in Contact Hypersensitivity Reactions
Author(s) -
BAADSGAARD O.,
LISBY S.,
AVNSTORP C.,
CLEMMENSEN O.,
LANGEVEJLSGAARD G.
Publication year - 1990
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1990.tb02914.x
Subject(s) - antigen , langerhans cell , immunology , cd1 , medicine , biology , natural killer t cell , cd8
Despite the critical role of the Langerhans cells in the induction of contact hypersensitivity reactions, non‐Langerhans antigen‐presenting cells in already sensitized individuals may play a role in the elicitation phase of a contact hypersensitivity reaction, following epicutaneous challenge with antigens, the number of CD1 + DR + epidermal Langerhans cells increased in a time‐dependent way and. concomitantly. CD1 − OKM5 + DR + epidermal non‐Langerhans cells appeared. In parallel with this, the capacity of epidermal cells to present both alloantigens and auto, nominal antigens increased, and 4 days after initiation of the contact hypersensitivity reactions 33–53% of the epidermal antigen‐presenting capacity was due to CD1 − non‐Langerhans antigen‐presenting cells. Thus, contact hypersensitivity skin reactions are accompanied by the appearance of non‐Langerhans antigen‐presenting cells capable of presenting both alloantigens and auto/nominal antigens.