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IgG Subclass Antibody Responses to Pneumococcal Polysaccharide Vaccine in Splenectomized, Otherwise Normal, Individuals
Author(s) -
AABERGE I. S.,
MICHAELSEN T. E.,
HEIER H. E.
Publication year - 1990
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1990.tb02822.x
Subject(s) - subclass , immunology , antibody , virology , medicine , biology , microbiology and biotechnology
Subclasses of IgG antibodies to pneumococcal polysaccharide serotypc antigens 4, 6A. and 23F were measured before and 4 weeks after vaccination with pneumoeoccal vaccine in young individuals splencetomized because of trautna and in a control group. An ELISA technique was applied. IgG2 anti‐pneuniococcal antibodies predominated before vaccination, especially against serotypes 4 anti 6A. The youngest individuals in the splenectomy group tended to have lower IgG2 antl‐pneumococcal antibody levels than the older ones. Vaccination induced antibodies of the IgGl and IgG2 subclasses, and in sotne individuals also of the IgG4 subclass. Splencetomy does not seem to inffuence the IgG subcllass paltern of antipneuniococcal antibodies.