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Impact of 90 Sr on Mouse Natural Killer Cells and their Regulation by Alpha Interferon and Interleukin 2
Author(s) -
GIDLUND M.,
BIERKE P.,
ÖRN A.,
AXBERG I.,
RAMSTEDT U.,
WIGZELL H.
Publication year - 1990
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1990.tb02808.x
Subject(s) - spleen , lytic cycle , bone marrow , interleukin 12 , lymph , natural killer cell , biology , in vitro , in vivo , interferon , lymphatic system , immunology , microbiology and biotechnology , cytotoxicity , pathology , medicine , cytotoxic t cell , biochemistry , virus
Male CBA/SU mice were exposed to ionizing radiation by intraperitoneal injection of the boneseekiag β‐emitter 90 Sr, NK‐cell lytic activities in spleen, peripheral blood, and lymph nodes were severely depressed or completely abolished. In contrast, production of the NK regulatory proteins alpha interferon (IFN‐ x ) and interleukin 2 (IL‐2) was normal 5–8 weeks after 90 Sr injection. IFN‐ x , produced in vivo or in vitro by cells from injected mice, was able to enhance strongly NK lytic activities. These data indicate that 90 Sr acts on the bone marrow, where it interferes with ihe maturation and seeding of NK precursor cells. The mechanisms regulating NK activities in peripheral organs remained relatively unchanged. Finally, we did not detect any major organ redistribution of NK cells as a result of 90 Sr irradiation.