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Role of Zinc in Interleukin 2 (IL‐2)‐Mediated T‐Cell Activation
Author(s) -
TANAKA Y.,
SHIOZAWA S.,
MORIMOTO I.,
FUJITA T.
Publication year - 1990
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1990.tb02805.x
Subject(s) - interleukin 2 , zinc , receptor , il 2 receptor , microbiology and biotechnology , chemistry , in vitro , scatchard plot , antibody , t lymphocyte , cell growth , interleukin , t cell , biology , immunology , cytokine , immune system , biochemistry , organic chemistry
In a serum‐free culture containing no zinc, zinc enhanced the proliferation of T cells in response to interleukin 2 (lL‐2), and also the in vitro production of lL‐2 by T cells. Although the lymphocyte proliferation was partially inhibited by anti‐IL‐2 antibodies, it was completely inhibited by anti‐IL‐2 receptor (CD25) antibodies. A Scatchard plot analysis showed that zinc induced the expression of high‐affinity receptors for IL‐2 on lymphocytes. The results indicated that zinc may be essentially required for IL‐2‐mediated T‐cell activation.