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Cellular Fibronectin in Rheumatoid Synovium and Synovial Fluid: a Possible Factor Contributing to Lymphocytic Infiltration
Author(s) -
WALLE T. K.,
VARTIO T.,
HELVE T.,
VIRTANEN I.,
KURKI P.
Publication year - 1990
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1990.tb02802.x
Subject(s) - synovial fluid , synovial membrane , infiltration (hvac) , pathology , fibronectin , immunofluorescence , monoclonal antibody , peripheral blood mononuclear cell , hyperplasia , inflammation , cellular infiltration , chemistry , antibody , immunology , medicine , cell , in vitro , materials science , osteoarthritis , biochemistry , alternative medicine , composite material
Mouse monoclonal antibodies against ED sequence‐containing cellular fibronectin (cFn) were used to show that Fn in the inflamed synovium is distinct from the major form of plasma Fn (pFn). An accumulation of cFn was seen at sites of hyperplasia of the rhcumatoid synovial membrane and in the walls of small vessels in the synovium by immunofluorescence microscopy. cFn was also found in rheumatoid synovial fluid by immunoblotting. Approximately one‐fifth of the T lymphocytes from rheumatoid synovial fluid bound to Fn, The binding of synovial fluid T cells was always higher than that from peripheral blood. These results have two implications. On the one hand, the cellular type of Fn may be an indicator of synovial inflammation. On the other hand, the deposition of Fn may be a factor contributing to the infiltration ol mononuclear cells into the synovium.