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Anti‐Idiotypic B‐Cell Lines from a Patient with Monoclonal Gammopathy of Undetermined Significance
Author(s) -
ANDERSSON M.,
HOLM G.,
LEFVERT A. K.,
MELLSTEDT H.
Publication year - 1989
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1989.tb02454.x
Subject(s) - monoclonal antibody , monoclonal , antibody , monoclonal gammopathy of undetermined significance , idiotype , b cell , immunology , microbiology and biotechnology , virology , biology , medicine
The B‐cell repertoire in a patient with benign monoclonal gammopathy of unknown significance was studied using Epstein–Barr virus transformation of peripheral lymphocytes. The presence of anti‐idiotypic B cells producing monoclonal antibodies that reacted with idiotypic determinants on the monoclonal immunoglobulin was verified. The two monoclonal anti‐idiotypic antibodies studied were of the IgM‐κ type. Such anti‐idiotypic antibodies may be part of an idiotypic network regulation of the monoclonal B‐cell population.