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Antibodies to β 2 ‐Microglobulin, the Light‐Chain Component of Class I Histocompatibility Molecules, Provide an Activation Signal to Human Lymphocytes
Author(s) -
HASHIMOTO S.,
McCOMBS C. C.,
MICHALSKI J. P.
Publication year - 1989
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1989.tb01219.x
Subject(s) - beta 2 microglobulin , polyclonal antibodies , microbiology and biotechnology , major histocompatibility complex , antibody , monoclonal antibody , antigen , immunoglobulin light chain , histocompatibility , lymphocyte , cd74 , chemistry , biology , human leukocyte antigen , immunology , mhc class i
Antibodies to β 2 ‐microglobulin (β 2 m), the light‐chain component of class I histocompatibility antigens, provide a strong co‐stimulatory signal to human lymphocytes in the presence of phorbol ester. This activation signal requires a high concentration it antibody, whereas the effect on responses to a mitogenic lectin is exclusively inhibitory over a broad dose range. A rabbit polyclonal and a mouse monoclonal antibody to β 2 m were similarly co‐stimulatory. Antibody to β 2 m was co‐stimulatory with phorbol ester, but not calcium ionophore, suggesting that class I antigens play a role in the initiation of the ‘first’ signal of a recently described two‐signal model of lymphocyte activation.