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Modulation of Both Interleukin 2 Receptor Expression and Interleukin 2 Production during Experimental Murine Trypanosoma cruzi Infection
Author(s) -
ROTTENBERG M.,
LINDQVIST C.,
KOMAN A,
SEGURA E. L.,
ÖRN A.
Publication year - 1989
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1989.tb01189.x
Subject(s) - trypanosoma cruzi , concanavalin a , interleukin 2 , biology , receptor , chagas disease , in vivo , immunology , interleukin , interleukin 4 , microbiology and biotechnology , cytokine , in vitro , parasite hosting , biochemistry , world wide web , computer science
A massive activation of T cells takes place during the early stages of a Trypanosoma cruzi infection in mice. We present data indicating that substantial amounts of Interleukin 2 (IL‐2) are secreted and IL‐2 receptors are expressed during the period of increased proliferation (4–7 days post infection). Both concanavalin A‐induced proliferation and IL‐2 production are markedly decreased later in the acute infection (around 3 weeks post infection). This proliferation cannot be restored by externally added IL‐2 Simultaneously, there is a drastic reduction in the number of both high‐and low‐affinity IL‐2 receptors. The reduction is not attributable to the elimination of a particular T‐cell population. In vivo administration of recombinant IL‐2 failed to improve resistance to T. cruzi parasites as measured by parasitaemia and mortality.