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Engraftment of T‐Depleted Major Histocompatibility Complex‐Mismatched Bone Marrow in T‐Deficient versus Natural Killer‐Deficient Recipients
Author(s) -
SCHOFER O.,
BUETTNER H. J.,
KRAEMER M.,
ZEPP F.,
MANNHARDT W.
Publication year - 1989
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1989.tb01166.x
Subject(s) - bone marrow , major histocompatibility complex , immunology , histocompatibility , bone marrow transplantation , biology , immune system , antigen , human leukocyte antigen
When bone marrow transplantation recipients undergo standard pre‐transplant immunosuppressive therapy, engraftment failures are significantly more frequent with the use of T‐depleted allogeneic donor bone marrow cells than with T cell‐containing allogeneic donor bone marrow cells. The relative importance of T versus natural killer (NK) cells in the rejection process of T‐depleted donor bone marrow cells remains debatable. Here, NK‐ and T‐deficient mouse mutants were transplanted across the same major histocompatibility complex (MHC) differences with homozygous or heterozygous T‐depleted bone marrow cells. Results show that under the experimental conditions described, residual host NK cells are almost exclusively responsible for the increased rejection rate.