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Vaccinia‐Interleukin 2 Recombinant Virus or Exogenous Interleukin 2 Does Not Alter the Magnitude or Immune Response Gene Defects of the Cytotoxic T‐Cell Response to Vaccinia Virus in Vivo
Author(s) -
MÜLLBACHER A.,
RAMSHAW I. A.,
COUPAR B. E. H.
Publication year - 1989
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1989.tb01092.x
Subject(s) - vaccinia , cytotoxic t cell , virus , biology , virology , orthopoxvirus , recombinant virus , poxviridae , immune system , lymphokine , major histocompatibility complex , recombinant dna , gene , immunology , in vitro , genetics
We investigated the role of interleukin 2 (IL‐2), a T cell‐derived lymphokine, in the generation of in vivo cytotoxic T‐cell responses to vaccinia virus. We made use of a recombinant vaccinia virus encoding and expressing the murine IL‐2 gene and recombinant IL‐2 to test the role of IL‐2 in the expression of major histocompatibility complex (MHC) class I determined immune response (Ir) gene defects in the response to vaccinia virus. IL‐2 expressed either by the vaccinia virus vector or exogenous IL‐2 does not alter Ir gene defects nor does IL‐2 under such conditions elevate the cytotoxic T‐cell response in general.