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Abnormal Helper‐Inducer/Suppressor–Inducer T‐Cell Subset Distribution and T‐Cell Activation Status are Common to All Types of Chronic Synovitis
Author(s) -
KINGSLEY G.,
PITZALIS C.,
KYRIAZIS N.,
PANAYI G. S.
Publication year - 1988
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1988.tb02435.x
Subject(s) - inducer , synovitis , immunology , ankylosing spondylitis , cd8 , medicine , rheumatoid arthritis , immunopathology , lesion , t cell , suppressor , antigen , biology , pathology , immune system , genetics , cancer , gene
We have previously shown that rheumatoid synovial T cells are virtually all helper‐inducer (CD4 + 4B4 + UCHL1 + ) rather than suppressor‐inducer (CD4 + 2H4 + ) cells. CD8 cells were also largely 4B4 + . In addition, the majority of T cells were HLA‐DR + . To investigate whether these findings were specific for rheumatoid disease, we studied the prevalence of these markers in a variety of chronic inflammatory arthropathies such as ankylosing spondylitis, Reiter's syndrome, and psoriatic arthritis. Again, almost 90% of the T cells were 4B4 + UCHL1 + and only 11% were 2H4 + ; 50% expressed the HLA DR antigen. Thus this phenotype distribution represents a final common pathway of chronic synovitis and may help to explain the immunopathology of the lesion.