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Regulation of Experimental Allergic Thyroiditis
Author(s) -
EISHI* Y.,
McCULLAGH P.
Publication year - 1988
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1988.tb02395.x
Subject(s) - thyroiditis , medicine , immunology , dermatology , thyroid
The susceptibility to experimental allergic thryoiditis (EAT) of rats that had previously been immunized against thyroglobulin was examined. Challenge with thryoglobulin 5 weeks previously conferred strong resistance to the induction of EAT after exposure to a sensitization protocol that was otherwise highly effective. Resistance to induction of EAT could also be conferred by the inoculation of spleen cells from thryoglobulin‐sensitized donors on the day of birth. Heavily irradiated spleen cells from sensitized donors were able to confer resistance on neonatal recipients, indicating that prolonged survival of the transferred cells was not required.