Premium
Histamine Inhibits Interleukin 1 Production by Lipopolysaccharide‐Stimulated Human Peripheral Blood Monocytes
Author(s) -
DOHLSTEN M.,
KALLAND T.,
SJÖGREN H.O.,
CARLSSON R.
Publication year - 1988
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1988.tb02379.x
Subject(s) - histamine , dimaprit , histamine h1 receptor , mepyramine , cimetidine , histamine h2 receptor , histamine h4 receptor , lipopolysaccharide , receptor antagonist , chemistry , histamine receptor , medicine , endocrinology , receptor , pharmacology , antagonist , biology
Histamine inhibited the production of interleukin 1 (IL‐1) induced by lipopolysaccharide (LPS) in cultures of purified human peripheral blood monocytes. The effect of histamine on IL‐1 production was dose‐dependent and significant at histamine concentrations of 10 −4 ‐10 −5 m . The histamine H2 receptor agonists dimaprit and 4‐methylhisiamine, hut not the H1 receptor agonists 2‐pyridylethylamine. aminoethylthiazole and 2‐methylhistamine, modulated the IL‐1 production in a similar manner to histamine. The inhibitory effects of histamine could be reversed by the H2 receptor antagonist cimetidine but not by the H1 receptor antagonist mepyramine. This indicates that the inhibitory effects of histamine on LPS‐induced IL‐1 production are mediated through H2 receptors on human peripheral blood monocytes.