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Peripheral T Cell Lymphomas: An Immunological Study of Seven Unusual Cases
Author(s) -
RAZIUDDIN S.,
LATIF A. B. A.,
ARIF S.,
AHAD A.,
ZAIDI A. Z.
Publication year - 1988
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1988.tb02376.x
Subject(s) - peripheral , pathology , medicine , immunology , peripheral t cell lymphoma , t cell , biology , immune system
A multiparameter study of malignant lymph node cells and peripheral blood lymphocytes of seven patients with peripheral T cell lymphoma is presented. The results of monoclonal marker studies showed three cases of helper‐suppressor T cell lymphoma (OKT4 + , OKT8 + ), one case of suppressor T cell lymphoma (OKT8 + ), and three cases of helper T cell lymphoma (OKT4 + ). Immunophenotypic heterogeneity of neoplastic T cells with expression of pan‐T antigens, OKT3 + , and OKT11 + (erythrocyte rosetting + ) was observed in most patients. Six of the seven cases tested showed la and DR antigens. No relationship was detected between patterns of reactivity with T cell reagents and histological types. When tested, the in‐vitro malignant T cells of five patients proliferated in response to concanavalin A (Con A), but had poor response to phytohaemagglutinin. The interleukin 2 receptors showed maximum expression on Con A‐activated T cells of five patients, and phytohaemagglutinin‐activated T cells of one patient. The neoplastic T cells (OKT4 + , OKT8 + ) of one patient studied had suppressor activity for IgG and IgA, and helper activity for IgM synthesis on pokeweed mitogen‐induced normal B cell differentiations.