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Antibody Response and Acquired Tolerance of A/J Mice: Age‐ and Immunogen‐Related Isotype Differences
Author(s) -
PONNAPPAN U.,
CINADER B.,
GERBER V.,
BLASER K.
Publication year - 1988
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1988.tb02366.x
Subject(s) - immunogen , isotype , antibody , biology , immunology , monoclonal antibody
In earlier work we have observed strain‐ and age‐related diversity of immunological ageing in inbred mice pretreated with tolerogen or left without pretreatment and then immunized. Different isotype show different age‐ and strain‐related changes. Here, we extend this isotype analysis from C57BL/6 and SJL to A/J. By comparison with the first two of these, animals of strain A/J show very little age‐related change, as judged by indirect plaque‐forming response. We have found that in A/J, as in SJL and CS7BL/6 mice, age‐related changes are isotype‐dependent. The age‐related changes in isotype predominance and magnitude differ for different determinants. They depend on the structural relation between the tolerance‐inducing or ‐sensitizing macromolecule and the immunogen.