Premium
Activation of Monocytes—More than One Process
Author(s) -
CARLSEN E.,
PRYDZ H.
Publication year - 1988
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1988.tb02363.x
Subject(s) - monocyte , interleukin 19 , interleukin , microbiology and biotechnology , thromboplastin , tumor necrosis factor alpha , tissue factor , immunology , chemistry , biology , cytokine , coagulation , medicine , interleukin 5
Monocytes and macrophages respond to a number of exogenous agents by alterations in metabolism and gene expression in a process loosely called ‘activation’. The question arises whether these alterations in cellular activity are the pleiotropic effects of one programmed activation process or result from separately programmed activation pathways. We report that certain cytokines (interleukin 1 (IL‐1α, IL‐1β) and interleukin 2 (IL‐2)) which all activate monocytes, induce the synthesis of thromboplastin (TPL) and (IL‐1β only) factor VII. Interferon‐γ (IFN‐γ) and tumour necrosis factor α (TNFα) do not induce monocyte procoagulant activity, although they both activate monocytes in several respects. Our data thus show that different states of activation are induced. Similar observations have been made by others using different systems.