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The Complete Amino Acid Sequence of Rat β 2 ‐Microglobulin
Author(s) -
SUNDELIN J.,
BJÖRCK L.,
LÖGDBERG L.
Publication year - 1988
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1988.tb02339.x
Subject(s) - cyanogen bromide , protein primary structure , peptide sequence , beta 2 microglobulin , sequence (biology) , amino acid , microbiology and biotechnology , sequence analysis , chemistry , peptide , guinea pig , complete sequence , biology , biochemistry , genetics , immunology , gene , genome
The primary structure of rat β 2 ‐microglobulin (β 2 m) was determined. It is a polypeptide of 99 amino acids with the following sequence: IQKTPQIQVY SRHPPENGKP NFLNCYVSQF HPPQIEIELL KNGKKIPNIE MSDLSFSKDW SFYILAHTEF TPTETDVYAC RVKHVTLKEP KTVTWDRDM. The primary structure was determined by NH 2 ‐terminal sequence analysis together with sequence determination of one cyanogen bromide fragment and one tryptic peptide. Of other known β 2 m sequences, rat β 2 m is most homologous to mouse β 2 m (83% identity). The rabbit, human, and guinea pig sequences are more distant, with 24,27, and 31% differences, respectively.