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IgG Subclass Deficiency in Patients with Down's Syndrome and Aberrant Hepatitis B Vaccine Response
Author(s) -
AVANZINI M. A.,
SÖDERSTRÖM T.,
WAHL M.,
PLEBANI A.,
BURGIO G. R.,
HANSON L. Å.
Publication year - 1988
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1988.tb01477.x
Subject(s) - subclass , immunology , medicine , antibody , hepatitis b vaccine , monoclonal antibody , antibody response , virology , vaccination , hepatitis b , hepatitis , hepatitis b virus , hbsag , virus
Seventeen adult patients with Down's syndrome (DS) and 19 adult healthy references were vaccinated with a hepatitis B vaccine in order to study the IgG subclass response. An enzyme‐linked immunosorbent assay (ELISA) using monoclonal antibodies specific for IgG subclasses was employed. In spite of normal levels of total IgG1 and normal or even high levels of IgG3 in the DS patients, a significantly lower IgG1 response to the vaccine was observed in trisomic patients than in the references.