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The Influence of T Cells on Homogeneous Immunoglobulins in Sera of Athymic Nude Mice during Aging
Author(s) -
AKKER T. W.,
TIOGILLEN A. P.,
SOLLEVELD H. A.,
BENNER R.,
RADL J.
Publication year - 1988
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1988.tb01461.x
Subject(s) - homogeneous , antibody , pathogenesis , immune system , immunology , nude mouse , monoclonal antibody , cell , medicine , endocrinology , biology , genetics , mathematics , cancer , combinatorics
In this study, results are presented which are in agreement with predictions made on basis of the ‘three‐Stage hypothesis’ on the development of benign monoclonal gammapathy (BMG). In a T‐cell depletion model, C57BL/Ka nude mice were shown to develop single and multiple homogeneous immunoglobulins (H‐Ig) during aging in the highest frequencies known so far. Ninety percent of the C57BL/Ka nude mice displayed one or more H‐Ig at 12 months of age. In a T‐cell supplementation model, infusion of corticosteroid resistant T cells into 9‐month‐old BALB/c nude mice resulted in a decrease in the Frequency of H‐Ig from 43% at 9 months down to 20% at 15 months of age. In contrast, the frequency of H‐Ig in the control group increased from 40% at 9 months up in 68% at 12 months. The results show that normally functioning T cells are essential for the generation of a normal, heterogeneous Ig spectrum; they further support the validity of the three‐stage hypothesis with regard to the role of an impairment of the T immune system in the pathogenesis of BMG.