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Changes in Idiotypic Predominance in the Anti‐Arsonate Response by Priming with Anti‐Idiotypic Antibodies
Author(s) -
GAYA A.,
ALSINET E.,
FREIXAS M.,
VIVES J.
Publication year - 1988
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1988.tb01457.x
Subject(s) - idiotype , antibody , priming (agriculture) , antibody response , monoclonal antibody , biology , immune system , immunology , microbiology and biotechnology , botany , germination
The predominant selection of CRI‐A‐bearing antibodies during the anti‐arsonate (ARS) response of A/J mice has been used as a model to analyse the mechanism involved in the process of clonal selection and establishment of predominance. In order to assess the importance of the affinity and adaptability of CRI‐A clones in this process, we tested the capability of a minor recurrent idiotype (id‐1A3), present in a CRI‐Aanti‐ARS monoclonal antibody (65–1 A3), to develop a normal anti‐ARS response. Our results show that the id‐1 A3 predominance, established by anti‐id‐1A3 administration was stable during the primary and secondary anti‐ARS response and that this predominance occurred concomitantly with tow levels of CRI‐A. Thus, a change in the idiotype predominance was achieved. In spite of the high levels of id‐1A3, the anti‐ARS antibody concentration, the affinity values, and the kinetics of the Immune response were similar to those of the control group. All these results show that CRI‐A clones arc not essential in the normal development of the anti‐ARS antibody response of A/J mice, and suggest that factors other than affinity could be involved in the stablishment of the CRI‐A predominance.