Premium
Expression of Restricted Immunoglobulin Isotypes in Plasmacellular Hyperplasia after Allogeneic Bone Marrow Transplantation
Author(s) -
SCHUURMAN H. J.,
HENDRIKS R. W.,
VERDONCK L. F.,
BAARLEN J.,
GAST G. C.,
SCHUURMAN R. K. B.
Publication year - 1987
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1987.tb02273.x
Subject(s) - isotype , immunoglobulin light chain , bone marrow , antibody , transplantation , immunoglobulin heavy chain , polyclonal antibodies , lymphoid hyperplasia , immunology , biology , microbiology and biotechnology , medicine , monoclonal antibody , lymphoma
Plasmacellular hyperplasia in lymphoid tissue was found in 4 out of 9 patients 1‐6 months after allogeneic bone marrow transplantation as treatment for leukaemia. In the plasma cell populations. 13‐85% expressed a single immunoglobulin light and heavy chain isotype (monotypic Ig expression). DNA analysis, using a DNA probe specific for heavy chain J H gene segments and for light chains, did not reveal the presence of clonally restricted B lymphocytes. The patients' sera lacked homogeneous immunoglobulins. We conclude that plasmacellular hyperplasia found after allogeneic bone marrow transplantation represents a polyclonal B‐cell expansion‐with a restriction in Ig isotype.