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Separate but Complementary Roles for the Two Forms of Interleukin 1 in the Growth of Transformed Human B Lymphoblasts
Author(s) -
GALLAGHER G.,
TAYLOR N.,
WILLDRIDGE J.
Publication year - 1987
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1987.tb02263.x
Subject(s) - lymphoblast , epstein–barr virus , biology , interleukin , cell growth , transforming growth factor , interleukin 4 , secretion , microbiology and biotechnology , virus , immunology , cell culture , cytokine , endocrinology , genetics
Epstein‐Barr virus (EBV)‐transformed human B cells were seeded at densities below their capacity for autostimulalory growth and the effects of interleukin I‐alpha (IL‐1‐α). interleukin 1‐beta (lL‐l‐β) and B‐cell growth factor (BCGF) were studied. When added separately. IL‐l‐α was able to support the growth of EBV‐transformed B cells, as was BCGF. In contrast, IL‐1‐β was unable to support the growth of these cells but was able to synergize with IL‐1‐α to promote cell growth. Further, the actions of BCGF and IL‐1‐α were seen to be synergistic. while those of BCGF and IL‐I‐β were not. The secretion of immunogiobulin was not affected by these reagents. These findings suggest separate, but complementary roles for the two forms of human IL‐1 in B‐cell growth.