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Three Kinds of Tumour‐Unique Surface Molecules on a Human T‐Cell Chronic Lymphocytic Leukaemia (T‐CLL) Detected by Monoclonal Antibodies
Author(s) -
JANSON C. H.,
TEHRANI M. JEDDI,
MELLSTEDT H.,
WIGZELL H.
Publication year - 1987
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1987.tb02257.x
Subject(s) - surface immunoglobulin , monoclonal antibody , antibody , antigen , cell , microbiology and biotechnology , chemistry , idiotype , t cell , chronic lymphocytic leukemia , biology , cancer research , immunology , b cell , leukemia , biochemistry , immune system
Mouse monoclonai antibodies recognizing cell surface molecules on tumour cells from a patient with a T‐cetl chronic lymphatic lcukacmia (T‐CLL) have been produced. Three different types of idiotype‐like cell Surface structures were identified. One molecule had a relative molecular weight (M r ) of 90,000 under non‐reduced conditions and of 42,000 upon reduction, which corresponds well to the T‐cell receptor for antigen (T t ). The two other molecules, which also behaved like unique tumour markers, have not previously been described, to our knowledge. One molecule wasa monomer with an M r , of 74,000–80,000 when non‐reduced and 80,000 upon reduction. The other idiotypic molecule was a dimer with a non‐reduced M r of 74,000–80,000, and 38,000 after reduction.