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Matching of Host Genotype and Serotypes of Coxsackie B Virus in the Development of Juvenile Diabetes
Author(s) -
FOHLMAN J.,
BÖHME J.,
RASK L.,
FRISK G.,
DIDERHOLM H.,
FRIMAN G.,
TUVEMO T.
Publication year - 1987
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1987.tb02242.x
Subject(s) - serotype , genotype , host (biology) , juvenile , virology , biology , virus , genetics , gene
Thirty‐six consecutive paediatric patients (0‐16 years old) with recently contracted juvenile diabetes (IDDM) during 1982‐84 were included in the study. Sera were assayed for recent or current Coxsackie B virus (CBV) infection using a specific and sensitive IgM RIA. Eighteen patients (50%) had IgM against CBV 1‐5. The patients were also assayed for restriction fragment length polymorphism (RFLP) patterns with DNA probes coding for HLA‐DR and DQ beta chains. The CBV‐positive patients (n=18) had either RFLP patterns associated with HLA‐DR 3 or 4 or HLA‐DQ patterns III or IV beta. Two of the CBV negative patients had neither HLA‐DR 3 nor DR 4 and four of them had neither DQ patterns III nor IV. Eleven out of 18 CBV‐positive patients had HLA‐DQ III and DR 3 (61%) versus 5 out of 18 (28%) of the CBV‐negative patients. All 11 patients with serology positive for CBV 2,3, and 5 had HLA‐DR 4 and DQ IV patterns. This was significantly (P<0.01) different from all five CBV 4‐positive patients, who in contrast all had HLA‐DR 3 or HLA‐DQ III patterns. CBV 1‐positive patients (n=2) all had HLA‐DR 3, 4, and HLA‐DQ III, IV patterns. Thus CBV 4 seems to be significantly associated with a different host genetic constitution from at any rate CBV 2,3, and 5, and possibly CBV 1.