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Immunological Involvement in the Pathogenesis of Pristane‐Induced Arthritis
Author(s) -
BEDWELL A. E.,
ELSON C. J.,
HINTON C. E.
Publication year - 1987
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1987.tb02205.x
Subject(s) - pristane , arthritis , immunology , congenic , immune system , rheumatoid arthritis , pathogenesis , antibody , medicine , biology , chemistry , gene , genetics , hydrocarbon , organic chemistry
Evidence is presented that the development of arthritis induced in mice by 2,6,10,14‐tetra‐methylpentadecane (pristane) involves the immune response. Mice irradiated (500 rad) before injection of pristane failed to develop arthritis. By contrast, irradiated mice given lymphoid cells from normal donors and challenged with pristane developed arthritis. Other experiments showed that lymphoid cells from irradiated mice given pristane suppressed the development of arthritis in recipients challenged with pristane. Finally, the incidence of arthritis was significantly higher in CBA/Igb mice given pristane than in the allotypic congenic strain CBA/H, suggesting that a gene linked to the heavy chain immunoglobulin locus controls the development of arthritis.