Premium
The Role of Gamma Interferon in B‐Cell Activation
Author(s) -
PISCHEDDA F.,
KIRCHNER H.,
LEANDERSON T.
Publication year - 1987
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1987.tb01077.x
Subject(s) - clone (java method) , gamma interferon , interferon gamma , interferon , in vitro , secretion , limiting , antibody , t cell , b cell , biology , cell culture , cell , microbiology and biotechnology , immunology , chemistry , cytokine , immune system , biochemistry , genetics , gene , mechanical engineering , engineering
This study evaluates the role of gamma interferon in in vitro B‐cell activation. Two elones of an alloreactive helper T‐cell line were equally effective in activating B cells polyclonally to proliferate and to mature to immunoglobulin secretion. One of these clones produced high levels of gamma interferon, while the other clone did not. From these data we conclude that gamma interferon plays no limiting role in T‐dependent B‐cell activation.