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Differential Expression of DRw52‐Like Determinants Detected by Monoclonal Antibodies
Author(s) -
KONING F.,
GIPHART M.,
TERMIJTELEN A.,
BRUNING H.
Publication year - 1987
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1987.tb01055.x
Subject(s) - monoclonal antibody , microbiology and biotechnology , reactivity (psychology) , beta (programming language) , antibody , cell , monoclonal , immunology , biology , chemistry , medicine , pathology , genetics , alternative medicine , computer science , programming language
The reactivity of three monoclonal antibodies (MoAb) directed against DRw52‐like determinants was studied in relation to the reactivity of an anti‐DR MoAb using fluorescence‐activated cell sorter (FACS) analysis. The MCS‐7 MoAb reacted with all DRw52+cells and in addition with DR2+, DR4+, and a DR7+ cell. Both the I‐LR2 and the 7.3.19.1 MoAb reacted with DR3+, DR5+, and DRw6+ cells only. However, whereas the 1‐LR2 MoAb reacted strongly with all those cells compared with the anti‐DR MoAb, the 7.3.19.1 MoAb reacted strongly with DR3+ cells. The implications of this for the location of DRw52‐like determinants on DRβ chains is discussed.